PTK2 and colorectal carcinoma: Our result regarding the focal adhesion pathway (Figure 3) supports the view that GSK-3β (GSK3B, Table 1) regulated by PI3K-AKT/PKB signaling of FAK downstream was downregulated in the CRC patients, and also that β-catenin (CTNNB1, Table 1) was highly expressed by downregulation of the Wnt signaling inhibitor GSK-3β in the CRC patients.