Another finding relevant to the downstream region of the focal adhesion pathway is that the anti-apoptosis protein c-IAP (BIRC3, Table 1) [16], which is a negative regulator of caspases (e.g., CASP3, CASP8, CASP9), was also upregulated in the CRC patients. The gene discussed is CASP8; the disease is colorectal carcinoma.