Even apolipoprotein E (ApoE), which is the most relevant risk factor for developing late-onset AD, rather than being a mere Aβ chaperone, might be involved in complex-signaling pathways through its multiple receptors (LRPs), such as those bearing to the low-density lipoprotein receptor family (LDLR) (for review see [11]). This evidence concerns the gene LDLR and Alzheimer disease.