DNM2 and Charcot-Marie-Tooth disease, axonal, type 2FF: Although ubiquitous expression and the central role of DNM2 in endocytosis suggested an essential function in all tissues, DNM2 was found mutated in two tissue-specific human diseases: autosomal dominant centronuclear myopathy (ADCNM, OMIM 160150) and dominant intermediate Charcot-Marie-Tooth neuropathy (DI-CMTB, OMIM 606482) (Figure 1) [58], [59].