Several genes implicated in membrane remodeling and trafficking are mutated in different forms of human neuropathies (DNM2, MTMR2, MTMR13, NEFL, RAB7A, FGD4, FIG4, SH3TC2, LITAF/SIMPLE) and myopathies (MTM1, BIN1, DNM2, CAV3, DYSF) (reviewed in [1]). The gene discussed is FGD4; the disease is myopathy.