BIN1 and centronuclear myopathy: Loss of Amph resulted in severe disorganization and reduction of the T-tubules, similar to the triads defect observed in CNM patients with BIN1 mutations [36] and in Mtm1-deficient mice and mtm1-deficient Zebrafish, reinforcing the hypothesis that MTM1 and amphiphysin 2 work in the same pathway in skeletal muscle.