However, as noted for the replicative capacity of mammalian cells, HIV-1 replication efficiency is also directly correlated with cellular dNTP concentrations and proceeds with far greater efficiency in both tumor cells and PHA-stimulated CD4+ T cells, in which the average dNTP levels are 150–225 times higher than that of non-dividing MDMs [32], [33]. The gene discussed is CD4; the disease is neoplasm.