HMBS and peritoneal well differentiated papillary mesothelioma: So, in this experimental study on rats we have evaluated whether changes in UPS levels and activity into the adhered tissue occur along with the development of post-surgical peritoneal adhesions, and then we used the specific UPS inhibitor bortezomib [15–17] in order to ascertain the role that the UPS may have in the peritoneal adhesions formation.