APC and Familial prostate cancer: Several negative regulators of the Wnt pathway including the adenomatous polyposis coli (APC), secreted frizzled-related protein (SFRP1), dickkopf-related protein 3 (DKK3), and sex determining region Y-box 7 (SOX7) are hypermethylated in a high proportion of prostate cancers[24-26].