To investigate whether LSD1 regulates the EMT transition in lung cancer cells, we examined the expression of the key EMT transcriptional repressor TWIST1 and the EMT markers E-cadherin and N-cadherin in LSD1-over-expressing A549 cells (transfected with the Flag-LSD1 LSD1 over-expressing plasmid) and LSD1 knocked down H460 cells (transfected with the LSD1 siRNA plasmid, or treated with 4 mM pargyline). This evidence concerns the gene KDM1A and lung carcinoma.