In addition to SOD1, heritable mutation of two other genes are implicated in FALS, and associated with protein mislocalization and aggregation: the RNA-processing proteins fused in sarcoma (FUS), originally named translocated in liposarcoma (TLS), and TAR-DNA binding protein 43 (TDP43) [12]–[14]_ENREF_10_ENREF_10. Here, TARDBP is linked to Tumor Lysis Syndrome.