SOD1 and neuroblastoma: In order to examine the effects of aberrantly localized FUS and TDP43 on the folding of human wild-type SOD1 (wtSOD1), we transfected human neuroblastoma SH-SY5Y cells with expression constructs of wild-type and mutant FUS and TDP43, including the naturally occurring FUS cytosol-localizing truncation mutation R495x [24] and the missense mutant P525L [12], [18], as well as the experimentally-engineered cytosol-localizing triple missense tandem TDP43 mutation (K82A, R83A, K84A) in the nuclear localization signal (NLS; mutant named ΔNLS-TDP43) [25].