In other study, GLP-1 infusion significantly increased relative changes in brachial artery diameter from baseline flow mediated dilatation (%) (3.1 ± 0.6 vs. 6.6 ± 1.0%, p < 0.05) in type 2 diabetes patients with coronary artery disease [29], just as GLP-1 increased intracellular cAMP (from 5.7 ± 0.5 to 13.1 ± 0.12 pmol/mg protein) in rat cardiac myocytes [31]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.