CR1 and acute lymphoblastic leukemia: In these datasets, the AMICA1, DBC1, CD300LF, CR1, SEC14L4 and TMEM2 genes identified in our study as hypermethylated were down-regulated and the hypomethylated genes ACY3, FXYD2, and MYBPC2 were up-regulated with 2-fold differences in expression levels between ALL cells and control bone marrow cells [16] or peripheral blood mononuclear cells from healthy individuals [17] (Table 2) in at least one dataset.