The CpG site in the MYBPC2 gene was differentially methylated (Wilcoxon Rank-Sum test, P-value<0.001) between ALL cells of B-cell origin (BCP ALL, n = 16) and T-cell origin (T-ALL, n = 4), with hypomethylation in BCP ALL (median β-value = 0.04) and hypermethylation in T-ALL (median β-value = 0.75). This evidence concerns the gene MYBPC2 and acute lymphoblastic leukemia.