It was reported that SND could up-regulate B-cell lymphoma 2 (Bcl-2) protein and inhibit activation of Caspase-3 in ischemia-reperfusion cardiomyocytes, resulting in promoting mitochondrial function and reducing apoptosis, which might be responsible for the intervening effect of SND on ischemia injury [7]. This evidence concerns the gene CASP3 and ischemia.