Although nutritional compounds are important for the improvement of health, changes to diets, such as an increase of either fruit or vegetable consumption, as well as a reduction of refined carbohydrates and saturated and trans-fatty acids [98,99], are required, as food restriction can prevent obesity in humans [98,99] and mice deficient in the TLR5 [47]. Here, TLR5 is linked to obesity due to melanocortin 4 receptor deficiency.