Similarly, a lack of statistically significant difference was obtained when analysis was carried out in perimenopausal women with depression divided into five groups according to the presence and severity of hot flashes in relation to the levels of TNFα (P = 0.583), IL-6 (P = 0.719) and IL-10 (P = 0.745) in these five groups (Table 6). This evidence concerns the gene IL10 and major depressive disorder.