PRRT2 and Hyperglycemia: Both staurosporine and calphostin, an inhibitor of classic and novel PKC isoforms, block hyperglycemia-induced NF-κB activation [92, 260], and a specific PKCβ inhibitor (ruboxistaurin) prevents AGEs-induced ICAM-1 expression and leukocyte adhesion in HUVECs [261].