Total bone marrow seems to be a good source of samples for our study because (1) it reflects the “real” tumor bone marrow T-cell compartment, without manipulation of CD4 subpopulations by FACS or magnetic sorting and (2) normal and malignant plasma cells express no or very low levels of Foxp3 or ROR-γt (data not shown), suggesting that expression of genes is representative for the respective CD4+ T cell subpopulation [14, 15]. The gene discussed is CD4; the disease is neoplasm.