Extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which NF-κB, STAT3, COX-2, NOS, ROS, Akt (defined as transcription factors), anti-apoptotic proteins, growth factor receptor and multidrug-resistance proteins (defined as apoptosis related molecules) are involved [6–11]. The gene discussed is NFKB1; the disease is cancer.