Numerous lines of evidence have suggested curcumin suppressed cancer cell proliferation by reducing NF-κB signaling and its genetic targets, including cyclin D1, c-myc, Bcl-2, Bcl-xl, CIAP-1, COX-2, VEGF and matrix metalloproteinase (MMP) [35,36]. The gene discussed is NFKB1; the disease is cancer.