The Short Stature Homeobox containing gene (SHOX), mapped within the Pseudoautosomal Region 1 (PAR 1) of the X and Y chromosomes, is involved in the regulation of growth and is related to different diseases such as Turner syndrome (TS), Idiopathic Short Stature (ISS), Leri Weill dyschondrosteosis (LWD) and Langer disease (LS) [60]. The gene discussed is SHOX; the disease is Leri-Weill dyschondrosteosis.