MLH1 and hereditary nonpolyposis colon cancer: Taylor et al. analyzed by MLPA 215 UK patients referred for genetic testing on the basis of a family history consistent with autosomal dominant hereditary HNPCC and found 12 cases with deletions of one or more exons (six involving MLH1 and six MSH2), providing evidence that the overall mutation detection sensitivity in their series was increased by approximately 50% by the inclusion of MLPA, for an additional testing cost of about 10% [90].