BRCA1 and male breast carcinoma: Other studies have demonstrated that the detection rate of BRCA1 and BRCA2 rearrangements by MLPA increases in selected families, such as in the study reported by Woodward et al., who evidenced a high frequency of deletions/duplications in multiple case breast/ovarian families with a young age of onset (BRCA1) and in families containing at least one case of male breast cancer (BRCA2) [83].