Cancer drugs such as Imatinib (for the treatment of chronic myeloid leukemia), cetuximab, lapatinib, gefitinib (for the treatment of breast, prostate, kidney and ovarian cancers) also target both AKT and ERK in order to inhibit phosphorylation of FoxO3 [60]. The gene discussed is FOXO3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.