Although there was some evidence of a difference in the distribution of p-STAT3 by CNS metastasis status among these stage IV melanoma patients (p = 0.05); this small difference may not be clinically meaningful and may be attributable to the fact that there were more lung samples, which have higher p-STAT3 expression, in the group without CNS metastasis. The gene discussed is STAT3; the disease is melanoma.