To further test whether MSX-122 can also inhibit metastatic progression in an orthotopic mouse model of uveal melanoma micrometastasis [46], [47], melanoma OMM2.3 cells overexpressing HGF/TGF-β/CXCR4/MMP2 were inoculated into the posterior chamber of the right eye. This evidence concerns the gene MMP2 and melanoma.