Individuals with leptin insensitivity and high levels of leptin have parallel comorbidities to normal weight obesity such as chronic inflammation, type II diabetes, hypertension, and myocardial injury [http://www.asbp.org/siterun_data/about_asbp/position_statements/doc7270523281295654373.html]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.