NYX and congenital stationary night blindness: Defectsin this signaling cascade result in loss of the ERG b-wave, and a class of humandiseases called complete congenital stationary night blindness (CSNB) or CSNB1.Previous data showed that mutations in nyctalopin predicted to cause a loss ofnyctalopin in humans and mouse, result in the absence of b-wave in the ERG [1], [2], [6], indicatingsignaling between the GRM6 receptor and TRPM1 is defective.