Its etiology was unclear [12], as rhabdomyolysis was not observed during preclinical studies: only sporadic increased serum creatine phosphokinase (CPK) was found in repeat-dose studies in Cynomolgus monkeys, with no macro- or microscopic findings suggestive of trabectedin-induced rhabdomyolysis. Here, PIK3C2A is linked to rhabdomyolysis.