APOE-4 may influence AD pathology interacting with APP metabolism and Aβ accumulation, enhancing the hyperphosphorylation of tau protein and NFT formation, reducing choline acetyltransferase activity, increasing oxidative processes, modifying inflammation-related neuroimmunotrophic activity and glial activation, altering lipid metabolism, lipid transport, and membrane biosynthesis in sprouting and synaptic remodeling, and inducing neuronal apoptosis [9, 29–37]. This evidence concerns the gene MAPT and Alzheimer disease.