APOE and Alzheimer disease: Others found no differences after 6 months of treatment with tacrine among APOE genotypes, but after 12 months the CIBIC scores revealed that APOE-4 carriers had declined more than the APOE-2 and APOE-3 patients, suggesting that a faster rate of decline was evident in the APOE-4 patients, probably reflecting that APOE-4 inheritance is a negative predictor of treatment of tacrine in AD [143].