Harold et al. [52] undertook a two-stage genome-wide association study (GWAS) of AD involving over 16,000 individuals and found association with SNPs at two loci not previously associated with the disease, at the CLU (Clusterine, APOJ) gene (rs11136000) and 5′ to the PICALM gene (rs3851179). This evidence concerns the gene CLU and Alzheimer disease.