APOE and atherosclerosis: Since ApoE can protect against cardiovascular disease (e.g., coronary artery disease) via hepatic removal of atherogenic remnant proteins, sequestration of cholesterol from vessel walls, and local antioxidant, antiplatelet, and anti-inflammatory actions, it has been postulated that APOE gene transfer might ameliorate a hyperlipidemic profile and exert a beneficial effect at lesion sites to prevent or regress atherosclerosis [217].