Jun et al. [54] determined whether genotypes at CLU, PICALM, and CR1 confer risk for AD and whether risk for AD associated with these genes is influenced by APOE genotypes in 7,070 cases with AD, 3,055 with autopsies, and 8,169 elderly cognitively normal controls, 1,092 with autopsies, from 12 different studies, including white, African American, Israeli-Arab, and Caribbean Hispanic individuals. Here, PICALM is linked to Alzheimer disease.