APOE and Alzheimer disease: Genome-wide association studies (GWASs) in AD highlight over two dozen novel potential susceptibility loci beyond the well-established APOE association, including GAB2 (GRB2-associated binding protein 2), galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1), and at least three replicated loci in hitherto uncharacterized genomic intervals on chromosomes 14q32.13, 14q31.2, and 6q24.1, probably implicating the existence of novel AD genes in these regions [91].