MAPT and Alzheimer disease: Hippocampal and entorhinal cortex atrophy on MRI scan of brain [7], parietotemporal hypometabolism on 18FDG PET [8], increased amyloid uptake using PET [9], and decreased amyloid beta-42 (Aβ42) with increased tau/phospho-tau levels in the cerebrospinal fluid (CSF) [10, 11] each significantly predict transition from MCI to AD.