Through the production of VEGFA, TGFβ, and tumor necrosis factor-α (TNFα), tumor cells enhance the expression of the chemoattractants S100A8 and S100A9 in lung endothelium and myeloid cells, which in turn promote tumor cell homing and adhesion to the metastatic site [81, 82]. This evidence concerns the gene S100A8 and neoplasm.