PGF and neoplasm: Coenegrachts et al. demonstrated that the selective neutralization of host-derived bone-derived placental growth factor (PlGF) by anti-mouse alphaPlGF reduced the engraftment of tumor cells in the bone, inhibited their interaction with matrix components, reduced the incidence, number, and size of bone metastases, and preserved bone therefore inhibiting both the progression of metastasis and the settlement of tumor in the bone [100].