Patients with a BNP > 49 pg/mL had a greater mortality rate (P = 0.0001), a greater risk of development of severe sepsis (P = 0.0001) and septic shock (P = 0.0001), and a higher rate of the triple composite outcome (unadjusted odds ratio [OR] = 1.9, 95% confidence interval [CI] = 1.6 to 2.1; P < 0.001). The gene discussed is NPPB; the disease is Sepsis.