In fact, TNF −308G was both associated with TB and protective for autoimmunity, TNF −238A allele was protective for autoimmunity but represented a susceptibility factor for TB, and the haplotype −308A −238G was a protective factor against TB while, at the same time, it carried susceptibility for RA, SLE, and Sjögren's syndrome (SS) [35]. This evidence concerns the gene TNF and rheumatoid arthritis.