We reported that pretreatment of myeloma cells with combination of JSI-124 and bortezomib can recover DC dysfunction from loading the dying myeloma cells through the upregulation of Hsp90 and the downregulation of STAT3 phosphorylation and inhibitory cytokines production, and these DCs can generate to potent myeloma-specific CTLs. This evidence concerns the gene STAT3 and plasma cell myeloma.