There have been increasing reports of these alternative approaches, such as DCs pulsed with myeloma lysates [42–44], DCs pulsed with myeloma apoptotic bodies [43, 45, 46], DCs transfected with myeloma-derived RNA [36], DCs pulsed with myeloma-derived heat shock protein (HSP) gp96 [47, 48], or DC-myeloma cell hybrids [49–51]. Here, HSP90B1 is linked to plasma cell myeloma.