A number of candidate gene studies investigating interactions between maternal atopy and airway hyperresponsiveness have also been performed for 3 main groups of genes: immunity genes (CD14, IL13, CCL22, and CTLA4), the stress gene (fibroblast growth factor 1 (FGF-1)), and the MHC class I antigen gene (HLA-G) gene. The gene discussed is FGF1; the disease is airway hyperresponsiveness.