In ovarian cancers, mutant or isoforms of EGFR RTKs transactivate signaling transduction cascades such as PI3K/AKT and Ras/Raf/MEK/MAPK/ERK that result in diverse effects, including cell proliferation, dedifferentiation, adhesion, migration, invasion, angiogenesis, and apoptosis evasion [177–183]. The gene discussed is EGFR; the disease is ovarian carcinoma.