Since cancer stem cells (CSCs) are predominantly quiescent, have upregulated DNA repair capacity, are noncommittal to apoptosis, and overexpress ATP-binding cassette (ABC) drug efflux transporters, for example, ABCG1 (MDR1/P-glycoprotein/Pgp), ABCG2, and breast cancer resistance protein (BCRP), and a profusion of cancer gene signatures, they sustain the succession of clonal tumor cell proliferation and repopulation in the tumor microenvironment [2, 22, 25, 26, 28–38]. The gene discussed is ABCG2; the disease is cancer.