The observation that crosstalk between the EGFR and IL-6R signaling through JAK/STAT3 mediates EMT in ovarian cancers further adds to the number of exploitable opportunities that are emerging to target the molecular intricacies that underscore the aggressive phenotype of ovarian cancer and its recurrence in patients [258, 263, 264]. The gene discussed is IL6R; the disease is ovarian carcinoma.