MUC16 is overexpressed in EOC and correlates with decreased E-cadherin, elevated N-cadherin and vimentin levels, and heightened invasivesness, tumorigenesis, tumor cell proliferation, and metastases, as confirmed by MUC16 knockdown which completely abolished the development of subcutaneous tumors in nude mice [222]. The gene discussed is MUC16; the disease is neoplasm.