Reversal of MDR in ovarian cancer cell lines is possible with siRNA knockout of ABCB1 (MDR1) and ABCB4 (MDR3) genes [410, 411], combination drug treatments [412, 413], chitosan/pshRNA plasmid nanoparticle targeting of MDR1 genes [414], and perturbation of P-glycoprotein N-glycosylation [415]. The gene discussed is ABCB4; the disease is ovarian cancer.