Nonetheless, the sensitivity and reliability of ovarian cancer biomarkers may be confounded by several characteristics of the disease such as mutations in the BRCA1 or BRCA2 genes and their arcane absence in sporadic ovarian cancer, diverse genetic risk factors, unidentified initiation and progression elements, molecular tumor heterogeneity, and transition time between different stages of the disease. This evidence concerns the gene BRCA1 and ovarian cancer.