F2R and ovarian carcinoma: In ovarian carcinoma cells, activated MMP1-PAR1 induces the release of angiogenic factors such as interleukin-8 (IL-8) and growth-regulated oncogene-alpha (GRO-α) which, through paracrine signaling, act on endothelial CXCR1/2 to effect endothelial cell proliferation, tube formation, and migration [110].