BRCA1 and ovarian carcinoma: Ovarian cancers with mutated BRCA1/2 genes are particularly sensitive to agents that cause DNA double strand breaks (DSBs) and DNA interstrand cross-links, like the platinum compounds (e.g., cisplatin and carboplatin) and poly(ADP-ribose) polymerase (PARP) inhibitors (e.g., olaparib, iniparib, veliparib) [128–132].