IKBKB and cancer: Using specimens from patients with IKKβ-positive ovarian tumors and ovarian cancer cell lines, a recent study showed that activation of the NF-κB pathway by downregulating IKKβ activity with highly specific kinase inhibitors or through short hairpin RNA (shRNA), depletion of IKKβ correlated not only with a number of cellular expressions associated with the invasive phenotype of this cancer, but also with poor OS [80].