CD274 and neoplasm: The presence of a complex immune suppressive network in the tumor microenvironment includes, but is not limited to, (a) Tregs, (b) myeloid-derived suppressor cells (MDSCs) along with their mediators (i.e., IL-10, TGF-β, GM-CSF, PGE2, B7-H1, PD-1, and Arginase I), (c) functionally impaired immune cells, and (d) tumor-associated macrophages (TAMs) and their mediators such as nitric oxide which effectively halts the antitumor immunity [45].