CCN1 and familial pancreatic carcinoma: Cyr61 has been found to play a critical role in pancreatic cancers and aggressive PDAC cell lines through the induction of EMT and the expression of mesenchymal/stem cell markers; additionally, stem cell-like Cyr61 silencing reduces the aggressive behaviors of malignant cells by obliterating the interlinking pathological events, such as EMT reversal, blocking the expression of mesenchymal traits, and inhibiting migration [23].