Furthermore, tumor-derived TNC has been demonstrated to promote the survival and outgrowth of pulmonary micrometastases by enhancing the fitness of metastasis-initiating cancer cells through increased expression of stem cell signaling components, such as leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) and musashi homolog 1 (MSl1) [49]. Here, LGR5 is linked to neoplasm.