Although the activation of the PI3K/PKB, ERK1/2 MAPK, and NF-κB signaling pathways by diverse matricellular proteins appears to be a recurrent theme by which matricellular proteins modulate tumor survival and growth, there is still much to elucidate on how exactly these matricellular proteins modulate and orchestrate the entire metastastic process. The gene discussed is AKT1; the disease is neoplasm.