NFKB1 and neoplasm: Although the activation of the PI3K/PKB, ERK1/2 MAPK, and NF-κB signaling pathways by diverse matricellular proteins appears to be a recurrent theme by which matricellular proteins modulate tumor survival and growth, there is still much to elucidate on how exactly these matricellular proteins modulate and orchestrate the entire metastastic process.