It has been postulated that TNC promotes angiogenesis by acting as a chemoattractant for endothelial cells, initiating endothelial cell differentiation, survival, proliferation involving integrin αvβ3, and vascular endothelial growth factor (VEGF) and also by stimulating VEGFA expression, resulting in endothelial cell migration, proliferation and the subsequent formation of capillaries in the tumor [84, 86]. Here, VEGFA is linked to neoplasm.