Further, glioblastoma patients involved in antiangiogenic therapies, including VEGF ligand-trapping antibody and bevacizumab (a humanized monoclonal antibody that binds to VEGF-A), showed a proinvasive adaptive response where multifocal recurrence of tumors developed during the course of the therapy [186–188]. The gene discussed is VEGFA; the disease is glioblastoma.