Several other factors have been recently identified as inducers of lymphangiogenesis, including hepatocyte growth factor, Angiopoietins 1 and 2 (Ang-1, -2), fibroblast growth factor-2 (FGF-2), platelet-derived growth factor-BB (PDGF-BB), growth hormone (GH), adrenomedullin (AM), insulin-like growth factors 1 and 2, and endothelin-1 (ET-1) (the involvement of these factors in tumor lymphangiogenesis is summarized in Table 2). This evidence concerns the gene EDN1 and neoplasm.