The existence of an influence of Wnt/β-catenin on PPARγ expression has been reported in 2000 when Ross et al. [117] described that Wnt signaling prevented the adipogenesis by silencing PPARγ expression; however, the interaction between PPARγ and Wnt stretches out the adipogenesis and has been described in several processes where ROS production and oxidative stress are important such as aging, Alzheimer's and Parkinson's diseases, diabetes, hepatic stellate cells activation, liver fibrosis, and cancer [6, 118–121]. This evidence concerns the gene PPARG and cancer.