In a previous paper about megaloblastic anemic patients, we found falsely normal serum Cbl levels only in alcoholics [12]; out of 101 adult patients with megaloblastic anemia, normal Cbl serum levels, normal serum, and RBC folate levels were found only in 3 patients, all alcohol dependent, while in another, alcoholic borderline vitamin B12 serum levels were found. Here, CBL is linked to megaloblastic anemia.