Indeed, several studies have indicated that PPAR-γ ciaos can prevent or attenuate neurodegeneration [23-25] and have beneficial effects in the amelioration of experimental autoimmune encephalomyelitis (EAE) [26-31] which could be explained in part because of anti-inflammatory action exerted through PPAR-γ activation in glial cells [14,32-34]. Here, PPARG is linked to experimental autoimmune encephalomyelitis.