Consequently, the goals of this study were to determine 1) whether SPARC sensitized glioma cells to radiation or chemotherapy, 2) whether targeting SPARC decreased tumor cell survival, 3) whether HSP27 inhibition was a better target to suppress SPARC-induced glioma cell survival, and 4) determine whether HSP27 inhibition suppressed SPARC-induced AKT activation and survival. This evidence concerns the gene HSPB1 and central nervous system cancer.