However, a high incidence (4/15 cases) of Notch1 mutation in PEST domain was reported in Indian T-ALL patients [9], while lower incidence was described from a study in Chinese T-ALL patients (5/77, 6.5%) [15], as well as in Turkish patients (7%) and German patients (8.2%) [7,18], the difference may due to the racial diversify. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.