To address whether antigen-dependent lymphoma rejection depends on IFN-γ signaling in the host or in the tumor cells, OVA-GFP-expressing wild-type lymphoma cells were inoculated into either IFN-γ−/− or IFN-γR−/− mice, and on the other hand, antigen-expressing lymphoma cells deficient for either the IFN-γ receptor or STAT1 were inoculated into wild-type mice. This evidence concerns the gene IFNG and neoplasm.