By forcing miR-29a expression in vitro in the ovarian cancer cell line HEYA8, we confirmed that a number of the genes anti-correlated with miR-29a—DNMT3A, DNMT3B, CDC6, CBX1, MYBL2, and TIMELESS (four of which were predicted direct targets)–were repressed by miR-29a (Figure 6C), which demonstrated these gene targets as relevant in both the in vitro functional models as well as the human tumor specimens; one gene tested, SAE1, showed anti-correlations but no functional repression. The gene discussed is DNMT3B; the disease is ovarian cancer.