In general, more aggressive breast cancers (MDA-MB-231, SUM159PT, BCCL2, BCCL3) had lower levels of TMX1 and SOD1 relative to the luminal MCF-7 cells, and showed up-regulated expression of TMX3, Foxo1, GSS and SOD2 (Fig. 5). The gene discussed is FOXO1; the disease is breast cancer.