Disrupted mGluR2/3 and/or mGluR7 receptor function in the forebrain has also been implicated in deficits in cognitive processing often diagnosed in patients with schizophrenia [69], with findings from several preclinical models of schizophrenia as well as from postmortem studies showing decreased levels of mGluR2/3 receptors, predominately in the PFC [70], [71]. The gene discussed is GRM2; the disease is schizophrenia.