To understand how Heme/HO-1, CXCL10/CXCR3 and STAT3 are involved in the pathogenesis of CM [3], [4], [5], as well as which tissues are involved in the Heme/HO-1 or CXCL10/CXCR3 or STAT3 pathways, and how their expression are regulated in malaria, we conducted a study focus on clarifying the roles of Heme/HO-1, CXCL10/CXCR3 and STAT3 in CM pathogenesis utilizing a well established experimental cerebral malaria (ECM) model, validating results in appropriate in vitro methods. This evidence concerns the gene STAT3 and malaria.