A recent study in Ghanaian patients demonstrated an association between fatal CM and increased serum and cerebrospinal fluid (CSF) levels of proinflammatory and proapoptotic factors including CXCL10, IL-1ra, sTNFR1, sTNFR2 and sFas and decreased serum and CSF levels of neuroprotective angiogenic growth factors (PDGFb) [3]. Here, PDGFB is linked to cutaneous mastocytosis.