CCL1-mediated Ca2+i mobilization through CCR8 has been described in cells expressing the receptor endogenously, e.g. monocytes [10], HL-60 clone 15 [14], IL-2-activated natural killer cells [28], T cell lines [29], BW5147 cells [17], and U87 malignant glioma cells [30]. Here, IL2 is linked to malignant glioma.