SPP1 and carcinoma: In close agreement with these results, qRT-PCR analysis indicated a down-regulation of pro-inflammatory transcripts in CT26 carcinomas grown in integrin β3-deficient compared to WT mice (Figure 6B), with significant decrease in S100A9, interleukin 1β (IL-1β), interferon-γ (Ifn-γ) and osteopontin (Opn) expression.