In high-grade ovarian cancer cells, we recently showed that H2O2 mediates the EGF-induced down-regulation of E-cadherin expression in SKOV3 ovarian cancer cells and suggested that the lack of an effect of EGF on E-cadherin in OVCAR3 cells may reflect an uncoupling of EGFR activation from H2O2 production [22]. The gene discussed is CDH1; the disease is ovarian carcinoma.