They identified eight SNPs (SNP1 to SNP8) in SEPTIN12. Among them, three synonymous variants (SNP3 or 210G>A, SNP4 or 225G>A, and SNP6 or 423G>C) were more prevalent in the SCOS patients, but their functional significance still remains to be explored. The gene discussed is SEPTIN12; the disease is small cell osteogenic sarcoma.