Similarly significant positive correlations exclusively within the relatives group were also found between aTreg frequencies and all measured SLE-associated plasma IgG autoantibodies: anti-dsDNA (within unaffected relatives: RSpearman = +0.23 [P = 0.01]), anti-SSA (RSpearman = +0.24 [P = 0.007]), anti-Sm (RSpearman = +0.40 [P = 8E-6]), and anti-nRNP (RSpearman = +0.31 [P = 0.0006]), but not IgM anti-dsDNA (Fig. 4, Table 2). This evidence concerns the gene RO60 and systemic lupus erythematosus.