IL2RA and systemic lupus erythematosus: Subsequently modeling the functional effect of IL2RA genetic variation and relating it to aTreg frequencies, it turned out that IL-2-CD25 interaction was indeed likely to trigger aTregs in the unaffected relatives, while in SLE patients IL-2/CD25-mediated effects were rather opposed to aTreg effects, supporting the notion that IL-2 triggered primarily T-effector cells in manifest SLE.