This is supported by the now well-documented characteristic reduction or even absence of surface CD25 on likely dysfunctional Tregs in SLE [26], [27], which was indicative for their known reduced suppressive function [24] and ‘dissociated’ from the often proportionally increased Foxp3 expression in SLE [28], [53]. The gene discussed is FOXP3; the disease is systemic lupus erythematosus.