To confirm whether inverse IL2RA-aTreg coreferentialities in patients and unaffected relatives were a valid result, we optimized a second independent IL2RA model for coreferentiality between the five initially used IL2RA SNP scores and aTreg frequency in the SLE patients group, and found that this IL2RA model was also similar to the initial one as was that optimized with CD247 SNPs in controls (Table 5). This evidence concerns the gene IL2RA and systemic lupus erythematosus.