For other reasons, we had typed our subjects for 24 SNPs covering the CD247 locus (Table S1) that encodes the CD3ζ chain, the major TCR signal transducer that is characteristically downregulated and replaced in SLE T-cells [44], which is a causal factor for transcriptional IL-2 repression [45]. The gene discussed is IL2; the disease is systemic lupus erythematosus.