CDKN2A and colorectal cancer: Although Wettergren et al (2010) [59] reported no effects of the MTRR 66G>A variant on p16INK4A hypermethylation in the mucosa of colorectal cancer patients, de Vogel et al (2009) observed that MLH1 hypermethylation among female colorectal cancer cases was inversely associated with carriage of the MTRR 66G>A variant [60].